Capsule seed

Details Capsule seed Capsule seed

A - Human Necessities

61

K

A61K 51/12 (2006.01) A61K 41/00 (2006.01) A61M 36/12 (2006.01)

Patent

CA 2370532

The present invention relates to a radioactive or activatable seed comprising a closed and self-supported casing consisting of (a) a radioactive or activatable metallic material selected from the group consisting of a metal, an alloy and metal composite or mixtures thereof, optionally in combination with (b) a non-radioactive and non-activatable metallic material; wherein (a) comprises a radioactive nuclide selected from the group consisting Pd-103, Tm-170, Sr-90, Y-90, Yb-169, P-32, Ge-71, Se-75, Cl-36, Ta-182, Tl-204, Re- 188, W-188, Ce-144, Pr-144, Sn-123, Ru-106, Rh-106 and mixtures thereof, and/or an activatable precursor nuclide thereof selected from the group consisting of Pd-102, Rh-103, Tm-169, Y-89, Yb-168, P-31, Ge-70, Se-74, Cl-35, Ta-181, Tl-203, W-186, Sn-122 and mixtures thereof, excluding metallic Pd with natural abundance of Pd-102. Preferably the radioactive nuclide is Pd-103 or Tm-170 and/or the precursor nuclide is Pd-102 or Tm-169, respectively. The invention also relates to a method of preparation of the above radioactive or activatable seed by a) providing the body of a closed and self-supported casing; b) optionally inserting a radio-opaque marker and/or a filler; c) closing the casing; and d) optionally providing one or more coating(s).

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