Capsule system

Details Capsule system Capsule system

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 31/4436 (2006.01) A61K 31/455 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2363933

A capsule system for oral delivery of an active agent having low aqueous solubility generally includes, in combination with the active agent, a vehicle for preventing initial active agent dissolution within the gastrointestinal tract and an emulsifier for promoting self-emulsification of the active agent and vehicle in the gastrointestinal tract. A capsule shell is provided for encapsulating the active agent, vehicle and emulsifier with the shell being formulated to open upon ingestion into the gastrointestinal tract and release the active agent and vehicle.

La présente invention concerne un système de gélule destiné à l'administration orale d'une substance active ayant une faible solubilité dans l'eau qui comprend, de manière générale, en combinaison avec la substance active, un excipient empêchant la dissolution initiale de la substance active dans le tractus gastro-intestinal et un émulsifiant facilitant l'auto-émulsification de la substance active et de l'excipient dans le tractus gastro-intestinal. La gélule comporte une enveloppe permettant d'encapsuler la substance active, l'excipient et l'émulsifiant. Cette enveloppe est formulée pour s'ouvrir lors de l'ingestion dans le tractus gastro-intestinal et libérer la substance active et l'excipient.

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