C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/36 (2006.01) A23J 1/00 (2006.01) A23J 3/12 (2006.01) A23L 1/015 (2006.01) A61M 1/34 (2006.01) B01D 61/00 (2006.01) C07K 1/32 (2006.01) C07K 1/34 (2006.01) C07K 14/47 (2006.01) C07K 16/06 (2006.01) C07K 16/34 (2006.01) C12N 5/078 (2010.01) A61K 39/395 (2006.01)
Patent
CA 2487072
Methods for producing biological solutions such as immunoglobulins and in particular anti-D immunoglobulin substantially free of abnormal prion protein resulting therefrom. Specifically provided are methods for aggregation of prions and depth filtration of the biological solution to capture and remove abnormal and if desired, normal prion protein. The prion protein may then be eluted from the depth filter and filter washes and concentrated sufficient for detection at limits currently required by available assays.
L'invention concerne un procédé de production de solutions biologiques telles que des immunoglobulines et en particulier des anti-D immunoglobulines sensiblement exemptes de protéines prion anormales en résultant. L'invention concerne de manière spécifique des procédés d'agrégation de prions et de filtration en profondeur de la solution biologique, afin de capturer et d'éliminer les protéines prion anormales et le cas échéant normales. Ladite protéine prion peut être alors éluée du filtre en profondeur et des lavages de filtres et être suffisamment concentrée pour la détection à des taux couramment utilisés pour des essais biologiques disponibles.
Autenrieth Stephen M.
Van Holten Robert W.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Ortho-Clinical Diagnostics Inc.
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