Capture probe design for efficient hybridisation

Details Capture probe design for efficient hybridisation Capture probe design for efficient hybridisation

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2574917

Methods for selecting and designing optimal nucleic acid-based probe for improving the sensitivity of detection of a nucleic acid-based target are disclosed herein. The capture probes generated from these methods show a significant improvement in the sensitivity of detection. Improved probes as well as microarrays and kits comprising these probes are disclosed herewith.

L'invention concerne des procédés de sélection et de conception d'une sonde à base d'acides nucléiques optimale destinée à améliorer la sensibilité de détection d'une cible à base d'acides nucléiques. Les sondes de capture fabriquées à partir de ces procédés présentent une amélioration significative quant à la sensibilité de détection. L'invention concerne également des sondes améliorées, ainsi que des microréseaux et des nécessaires comprenant ces sondes.

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