Carba derivatives of somatostatin and process therefor

Details Carba derivatives of somatostatin and process therefor Carba derivatives of somatostatin and process therefor

C - Chemistry, Metallurgy

07

K

530/7.26

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1083143

CARBA DERIVATIVES OF SOMATOSTATIN AND PROCESS THEREFOR Compounds of the formula I Image in which X is (CH2)k wherein k is an integer from 1 to 9, or (CH2)n- S-(CH2)m wherein m and n each is an integer from 1 to 4 and Y is Trp or D-Trp, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula I are useful for the management of diabetes and the treatment of acromegaly in mammals. Compositions and methods for their use are also disclosed. -1-

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