Carba-nucleoside analogs for antiviral treatment

Details Carba-nucleoside analogs for antiviral treatment Carba-nucleoside analogs for antiviral treatment

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/4188 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2722084

Provided are imidazol [1,5-f] [1,2.4]triazinyl, imidazol [1,2,4]triazinyl, and [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucleosides of formula I nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Wherein X1 or X2 is indepently C-R10 or N and wherein at least one of X1 or X2 is N.

L'invention porte sur des imidazol [1,5-f] [1,2,4]triazinyl, imidazol [1,2,4]triazinyl, et [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucléosides de formule I1, sur des nucléosides phosphates et promédicaments de ceux-ci. Les composés, compositions et procédés sont utiles pour le traitement d'infections par un virus de la famille Flaviviridae, en particulier des infections de l'hépatite C. Dans la formule, X1 ou X2 est indépendamment C-R10 ou N et au moins l'un de X1 ou X2 est N.

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