C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 263/10 (2006.01) C07C 45/59 (2006.01) C07C 57/26 (2006.01) C07C 57/60 (2006.01) C07C 405/00 (2006.01) C07D 263/14 (2006.01) C07D 317/72 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1220471
ABSTRACT OF THE DISCLOSURE The invention relates to carbacyclin derivatives of the general formula I Image I, wherein R1 represents the radical CH2OH or Image with R2 having the meaning of a hydrogen atom, an unsubstituted or sub- stituted alkyl, cycloalkyl, aryl or Image radical or a heterocyclic radical, or R1 represents the radical Image with R3 having the meaning of an acyl radical, preferably an alkanoyl or alkanesulphonyl radical, each having from 1 to 10 C-atoms, or having the meaning given for R2 or R1 represents the radical Image wherein m represents the number 1 or 2, X represents an oxygen atom or a CH2-group, A represents a trans-CH=CH- or a -C?C-group, W a free or functionally modified hydroxymethylene group, wherein the OH-group may be in the .alpha.-position or the .beta.-position, n may represent the number 1, 2 or 3, D represents a straight-chain alkylene group having from 1 to 5 C-atoms, E represents a -C?C-bond or a -CR6=CR7-group, wherein R6 and R7 are different from each other and each represents a hydrogen atom, an alkyl group having from 1 to 5 C-atoms or a halogen atom, preferably chlorine, R4 represents an unsubstituted or substituted ali- phatic hydrocarbon, cycloalkyl or aryl group or a heterocyclic group, R5 represents a free or functionally modifed hydroxyl group and, when R2 has the meaning of a hydrogen atom, the physiologically tolerable salts thereof with bases, a process for their preparation, and their use as agents for lowering blood pressure.
423413
Casals-Stenzel Jorge
Mannesmann Gerda
Raduchel Bernd
Schwarz Norbert
Skuballa Werner
Marks & Clerk
Schering Aktiengesellschaft
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