C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/235.01
C07C 405/00 (2006.01) C07D 317/16 (2006.01) C07D 317/72 (2006.01)
Patent
CA 1248525
ABSTRACT OF THE DISCLOSURE The present invention provides a carbacyclin derivative of the general formula Image (I), in which R1 represents either a radical of the general formula OR2 in which R2 represents a hydrogen atom or a C1-C4 alkyl radical or the radical Image or a radical of the general formula NHR3 in which R3 is hydrogen or 2,3-dihydroxypropyl, X represents a hydrogen atom or a fluoxine atom, A represents a trans-CH=CH- or-C?C- group, W represents a hydroxymethylene group where the OH group may be in the .alpha. - or .beta. -configuration, D represents the group Image wherein a straight chain alkylene group with 1 to 5 carbon atoms or a branched chain alkylene group with 2 to 5 carbon atoms, E represents a C?C group or a -CH=C(CH3) group R4 represents an alkyl radical with 1 to 7 carbon atoms and, when R2 is a hydrogen atom, salts with physiologically acceptable bases. The compounds have a hypotensive and bronchodilative action and are suitable for vasodilation and for inhibiting thrombocyte aggregation and gastric acid secretion.
432232
Casals-Stenzel Jorge
Mannesmann Gerda
Raduchel Bernd
Schillinger Ekkehard
Skuballa Werner
Marks & Clerk
Schering Aktiengesellschaft
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