C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/235.01
C07F 7/08 (2006.01) C07C 405/00 (2006.01) C07D 213/63 (2006.01) C07D 317/72 (2006.01)
Patent
CA 1245646
ABSTRACT OF THE DISCLOSURE The present invention provides carbacyclin derivatives of the general formula (I), in which R1 is the group OR2, in which R2 is hydrogen, alkyl of 1-4 carbon atoms, cycloalkyl of 5-6 carbon atoms, phenyl, 1- naphthyl or 2-naphthyl, the group -CH2-CO-aryl, in which aryl is phenyl, 1-naphthyl or 2-naphthyl each of which is substituted by phenyl, C1-C2-alkoxy, chloro or bromo, or R1 is a 5- or 6-mem- bered heterocyclic group with an N-, O- or S-atom, or R1 is the group NHR3, in which R3 is an organic carboxylic or sulphonic acid ester group having from 1 to 15 carbon atoms or is the group R2, A represents a trans-CH=CH- or -C?C group, W represents a free hydroxy-methylene group, D represents (I) the group Image wherein the carbon atom of the ring is attached to the radical represented by W or (II) -CH2-CH2-, -CH(CH3CH2-, or -C(CH3)CH2 group, E represents a -C?C- group or a -CH2-C(CH3) group, R4 is methyl or methyl, and R5 represents a free of functionally modi- fied hydroxy group and pharmaceutically acceptable salts thereof. As a substituted alkyl radical represented by R2, the group -CH2- CO-aryl should especially be mentioned. The compounds have a hypotensive and broncho-dilative action and are suitable for vasodilatation and for inhibiting thrombocyte aggregation and gastric acid secretion.
431622
Casals-Stenzel Jorge
Mannesmann Greda
Raduchel Bernd
Skuballa Werner
Town Michael H.
Marks & Clerk
Schering Aktiengesellschaft
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