C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/235.01
C07C 405/00 (2006.01) C07C 59/62 (2006.01) C07D 263/14 (2006.01) C07D 317/22 (2006.01)
Patent
CA 1275093
ABSTRACT OF THE DISCLOSURE The invention relates to carbacylin derivatives with the general formula I: Image I, where n is 1 or ?d R1 represents the group COOR2 where R2 is hydrogen or an alkyl with 1 to 4 C-atoms, R9 represents an alkyl group with 1 to 10 C-atoms or the group -C?C(CH2)m-R6 where m is a number from 1 to 8 and R6 is hydrogen, hydroxy or amino, Y is hydrogen, A is a trans- -CH=CH- or -C?C-group, W is a hydroxymethylene group or Image group where the OH group is in the .alpha. - or .beta. -position, D is a straight-chain saturated alkylene group with 1 to 5 C-atoms, or a branched chain saturated alkylene group with 2 to 5 C-atoms, E is a -C?C- group ?esents an alkyl group with 1 to 4 C-atoms, and R5 repre? a hydroxy group and, when R2 represents a hydrogen atom and its salts with physiologically tolerable bases. For its preparation a compound of the general formula II, Image II where R4, R5 R9, A, W, Y, D and E have the significance as quoted above, by reaction with a halogen alkane derivative with the general formula III
487598
Nieuweboer Bob
Sturzebecher Claus-Steffen
Vorbruggen Helmut
Marks & Clerk
Nieuweboer Bob
Schering Aktiengesellschaft
Sturzebecher Claus-Steffen
Vorbruggen Helmut
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