Carbacyclins, processes for their production and their use...

C - Chemistry – Metallurgy – 07 – F

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260/235.01

C07F 7/18 (2006.01) C07C 405/00 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1263382

ABSTRACT OF THE DISCLOSURE Carbacyclin derivatives of Formula I Image (I) wherein R1 is OR2 where/n R2 is hydrogen, or a C1-4 alkyl group, A is trans-CH=CH- or -C?C-, W is a hydroxy methylene group wherein the OH-group may be in the .alpha.- or .beta.-position, D is a branched chain alkylene group with 2 to 5 carbon atoms, E is - C?C- group, R4 is a C1-7 alkyl group, R5 is a hydroxy group or for said compounds wherein R2 is H, a phydiologically compatible salt thereof with a base are useful as medicinal agents.

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