Carbamate and oxamide compounds as inhibitors of cytokine...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/38 (2006.01) A61K 31/4427 (2006.01) A61K 31/4965 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07C 275/40 (2006.01) C07D 207/08 (2006.01) C07D 239/26 (2006.01) C07D 239/28 (2006.01) C07D 241/24 (2006.01) C07D 295/12 (2006.01) C07D 295/135 (2006.01) C07D 295/18 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01) C07D 307/12 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2448626

Disclosed are novel aromatic compounds of the formula (I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds. A representative example of the compounds of forumla (I) is (a).

La présente invention concerne de nouveaux composés aromatiques de formule (I), où G, E, W, Ar, X, Y et Z sont décrits. Lesdits composés sont utiles pour le traitement de maladies ou d'états induits par la cytokine tels que des maladies inflammatoires chroniques. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et des procédés de fabrication desdits composés. Un exemple représentatif des composés de formule (I) est (a).

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