C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/04 (2006.01) A61K 31/46 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2630222
The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5- HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclsoure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5 HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
Cette invention concerne de nouveaux composés de carbamate de formule (I), dérivés de benzimidazolone-carboxamide et utilisés comme agonistes du récepteur 5-HT4. Dans ladite formule, R1, R2, R3, R4, a et b sont tels que définis dans le mémorandum descriptif. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes d'utilisation desdits composés pour traiter des maladies associées à l'activité du récepteur 5-HT4, et des méthodes et des intermédiaires utiles pour la préparation desdits composés.
Choi Seok-Ki
Fatheree Paul R.
Goldblum Adam
Long Daniel
Marquess Daniel
Theravance Inc.
Torys Llp
LandOfFree
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