Carbamate compounds for use in the treatment of pain

A - Human Necessities – 61 – K

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A61K 31/27 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2439274

This invention is directed to a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1- C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

L'invention concerne une méthode de traitement de la douleur consistant à administrer à un sujet souffrant d'une douleur une dose thérapeutiquement efficace d'un composé choisi dans le groupe constitué par la formule (I) et la formule (II), dans lesquelles phényle est substitué en X par un à cinq atomes d'halogène choisis dans le groupe constitué par le fluor, le chlore, le brome et l'iode; et R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, et R¿6? sont indépendamment choisis dans le groupe constitué par hydrogène et alkyle C¿1?-C¿4?; dans lesquelles alkyle C¿1?-C¿4? est facultativement substitué par phényle (dans lesquelles phényle est facultativement substitué par des substituants indépendamment choisis dans le groupe constitué par halogène, alkyle C¿1?-C¿4?, cyano, nitro, amino et alcoxy C¿1?-C¿4?).

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