Carbamate compounds having n-substituted thiocarbamoyl group...

Details Carbamate compounds having n-substituted thiocarbamoyl group... Carbamate compounds having n-substituted thiocarbamoyl group...

C - Chemistry, Metallurgy

07

C

C07C 333/10 (2006.01) C07C 333/04 (2006.01) C07C 333/06 (2006.01) C07C 333/08 (2006.01) C07D 295/21 (2006.01)

Patent

CA 2217758

There is disclosed 3-N-substituted thiocarbamoyl-2-phenyl-1,3-propanediol carbamate, represented by structural formula (I), that is very effective for prophylaxis and treatment of central nervous system disorders including nervous muscular pain, epilepsy and cerebral apoplexy, wherein R1 and R2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl containing 1 to 8 carbon atoms and 5 to 7-membered aliphatic cyclic compound which may comprise two or less nitrogen or oxygen atoms directly unconnected, with a proviso that R1 and R2 both should not be hydrogen and the total number of carbon atoms of R1 and R2 ranges from 1 to 16.

Cette invention concerne un carbamate thiocarbamoyl-2-phényl-1,3-propanediol 3-N-substitué correspondant à la formule développée (I), lequel est très efficace lors de traitements prophylactiques et lors de traitements de troubles du système nerveux central comprenant les douleurs musculaires nerveuses, l'épilepsie et l'apoplexie cérébrale. Dans la formule (I), R1 et R2 peuvent être identiques ou différents l'un de l'autre et sont indépendamment choisis dans le groupe hydrogène, alkyle inférieur comportant de 1 à 8 atomes de carbone, et composé cyclique aliphatique ayant de 5 à 7 chaînons et pouvant comporter deux atomes d'azote ou d'oxygène ou moins directement non couplés, étant entendu que R1 et R2 ne doivent être tous deux de l'hydrogène et que le nombre total d'atomes de carbone de R1 et de R2 varie entre 1 et 16.

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