C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/34 (2006.01) A61K 31/36 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07C 311/06 (2006.01) C07C 311/13 (2006.01) C07C 311/16 (2006.01) C07C 311/19 (2006.01) C07C 311/29 (2006.01) C07D 209/88 (2006.01) C07D 213/40 (2006.01) C07D 213/42 (2006.01) C07D 213/65 (2006.01) C07D 213/71 (2006.01) C07D 307/52 (2006.01) C07D 317/58 (2006.01)
Patent
CA 2423744
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1~ is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: -S(=O)~2NR1~- and -NR1~S(=O)~2-; R1~ is a sulfonamido substituent; and, Q2~ is an acid leader group; with the proviso that if J is - S(=O)~2NR1~-, then Q1~ is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
La présente invention concerne certains composés actifs d'acide carbamique inhibiteurs de l'activité histone diacétylase (HDAC) et correspondant à la formule (I), dans laquelle: A est un groupe aryle; Q<1> est une liaison covalente ou un groupe aryle de tête; J est une liaison sulfonamide choisie parmi: -S(=O)2NR<1>- et -NR<1>S(=O)2-; R<1> est une substituant sulfonamide; et Q<2> est un groupe acide de tête; et des sels pharmaceutiquement acceptables, des solvates, des amides, des esters, des éthers, des formes chimiquement protégées, et des prodrogues de ceux-ci. La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et compositions, <i>in vitro</i> ainsi que <i>in</i> <i>vivo</i>, pour inhiber des pathologies proliférantes, tel que le cancer et le psoriasis.
Andrianov Victor
Dikovska Klara
Duffy James E. S.
Finn Paul W.
Gailite Vija
Prolifix Limited
Smart & Biggar
Topotarget Uk Limited
LandOfFree
Carbamic acid compounds comprising a sulfonamide linkage as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbamic acid compounds comprising a sulfonamide linkage as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbamic acid compounds comprising a sulfonamide linkage as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1614548