Carbamic acid derivatives and their use as metabotropic...

Details Carbamic acid derivatives and their use as metabotropic... Carbamic acid derivatives and their use as metabotropic...

C - Chemistry, Metallurgy

07

C

C07C 271/64 (2006.01) A61K 31/325 (2006.01) A61K 31/352 (2006.01) A61K 31/382 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) C07C 233/90 (2006.01) C07C 233/91 (2006.01) C07C 333/10 (2006.01) C07D 213/30 (2006.01) C07D 213/61 (2006.01) C07D 263/48 (2006.01) C07D 271/07 (2006.01) C07D 271/113 (2006.01) C07D 295/088 (2006.01) C07D 311/84 (2006.01) C07D 333/16 (2006.01) C07D 335/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2367368

The present invention relates to compounds of formula (I) wherein X signifies O, S or two hydrogen atoms not forming a bridge; A1/A2 signify, independently from each other, phenyl or a 6-membered heterocycle containing 1 or 2 nitrogen atoms; B is a group of formula (A), wherein Y signifies -O-, -S- or a bond; Z signifies -O- or -S-; or B is a 5-membered heterocyclic group of formulas (a, b, c or d). These compounds may be used as metabotropic glutamate receptor ligands in the control or prevention of acute and/or chronic neurological disorders.

L'invention concerne des composés de formule (I) dans laquelle X représente O, S ou deux atomes d'hydrogène ne formant pas un pont; A<1> et A<2> représentent, indépendamment, un phényle ou un hétérocycle à 6 chaînons contenant un ou 2 atomes d'azote; B représente un groupe de formule (A) dans laquelle Y représente O- ou S- ou une liaison; Z représente O- ou S-; ou B représente un groupe hétérocyclique à 5 chaînons de formules (a, b, c, d). Ces composés peuvent être utilisés comme ligands du récepteur de glutamate métabotropique dans la lutte contre ou la prévention de troubles neurologiques aigus et/ou chroniques.

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