Carbamic acid esters of benzazepines

Details Carbamic acid esters of benzazepines Carbamic acid esters of benzazepines

C - Chemistry, Metallurgy

07

D

167/209, 260/241

C07D 405/04 (2006.01) A61K 31/55 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1312863

ABSTRACT Compounds having the formula Image (I) wherein R1 is H, halogen, or C1-4 alkyl R2 is halogen, CF3, CN R4 is H, or halogen R5 is furyl, thienyl, pyridyl, or ring systems consisting of phenyl ortho condensed with a benzen, cyclo- hexan, cyclohexen, cyclopentan or cyclopenten ring in which rings one of the carbon atoms may be exchanged with oxygen, sulphur or nitrogen, and each of these ring systems option- ally are substituted with halogen, hydroxy or alkoxy with or not more than 4 carbon atoms, R6 is H or CH3 R7 is H or C1-4 alkyl R8 is H, alkyl, aralkyl, cycloalkyl, or aryl R9 is H, or R9 together with R8 form a piperidino, pyrrolidinyl, morpholino, or piperazinyl ring or a ring with the formula Image or R9 can be alkyl or alkoxycarbonyl with the formula CHR11 - ? - OR13 where R11 is H, CH3, (CH3)2CH, CH2CH(CH3)2, Image and R13 is H, alkyl, cycloalkyl, aralkyl, or a 2-acetamide group with the formula Image where R15 is H, CH3, C2H5, C3H8, or CH(CH3)2, and R14 is H, CH3, C2H5, C3H8 or CH(CH3)2 , and pharmaceutical-acceptable salts thereof. The compounds are useful as prodrugs for compounds active for the treatment of mental disorders.

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