C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 331/28 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07J 41/00 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)
Patent
CA 2048931
Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs This invention relates to compounds of the formula (see formula I) where R1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl: R2 is hydrogen, loweralkyl, loweralkenyl, formyl or cyano; R3 is hydrogen or loweralkyl: R4 is loweralkyl, arylloweralkyl, cycloalkyl, aryl, heteroaryl, heteroarylloweralkyl, (see formula II), or NR3R4 taken together constitute (see formula III, IV, V, VI or VII); R6 is hydrogen, loweralkyl or aryl; R6 is hydrogen, loweralkyl, aryl, arylloweralkyl, formyl, loweralkanoyl or arylloweralkanoyl, X and Y are independently hydrogen, nitro, amino, halogen, loweralkyl, loweralkoxy or hydroxy; or the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
Davis Larry
Effland Richard Charles
Olsen Gordon E.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst-Roussel Pharmaceuticals Inc.
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