Carbamoyl derivatives of bicyclic carbonylamino-pyrazoles as...

C - Chemistry – Metallurgy – 07 – D

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C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 497/04 (2006.01)

Patent

CA 2724215

There are provided bicyclic carbonylamino-pyrazoles of formula (I), wherein the variables are as specified in the claims, for use as medicament, in particular for the treatment of diseases due to the malfunctioning of protein kinases (PKs), such as cancer, pharmaceutical compositions comprising such carbamoyl derivatives, and their use as prodrugs of therapeutically active agents. Method of treatment and some new bicyclic carbonylamino-pyrazoles are also object of the present invention.

La présente invention concerne des carbonylamino-pyrazoles bicycliques de formule (I), dans laquelle les variables sont telles que définies dans les revendications, pour une utilisation comme médicament, en particulier pour le traitement de maladies dues au malfonctionnement de protéines kinases (PK), telles que le cancer, des compositions pharmaceutiques comprenant de tels dérivés carbamoyles, et leur utilisation comme promédicaments d'agents thérapeutiquement actifs. Linvention a également pour objet un procédé de traitement et quelques nouveaux carbonylamino-pyrazoles bicycliques.

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