C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/10 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) C07D 413/14 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2206466
This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
La présente invention concerne des hétérocycles carbamoylés qui sont des dérivés de l'acide oméga-phényl-oméga(3-pyridyl)-oméga-alcénoïque portant, sur le noyau phényle, un groupe oxazolyle ou oxazolinyle carbamoylé et qui sont utiles comme antagoniste du récepteur de la thromboxane et/ou inhibiteur de la thromboxane-synthase, ainsi que des formulations pharmaceutiques contenant ces dérivés, des méthodes d'utilisation et des procédés et intermédiaires relatifs à leur préparation.
Jakubowski Joseph Anthony
Mais Dale Eugene
Takeuchi Kumiko
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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