C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 269/02 (2006.01) C07C 273/18 (2006.01) C07C 333/02 (2006.01)
Patent
CA 2667714
The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.
La présente invention concerne la carbamoylation d'amines, de thiophénols, de mercaptans et de phénols mettant en AEuvre des azides organiques. Plus précisément, la présente invention concerne un procédé de génération de dérivés d'urée, de thiocarbamate et de carbamate, et repose sur la formation d'intermédiaires d'isocyanate, à partir d'un azide organique comme matériau de départ. La réaction selon l'invention est utilisée dans des applications pour la synthèse de nucléosides modifiés, d'oligonucléotides, ainsi que la modification, le marquage et la conjugaison de polymères et de biomolécules.
Azhayev Alex
Yagodkin Andrey
Mccarthy Tetrault Llp
Metkinen Chemistry Oy
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