Carbamoyloxymethylalkylcarbapenem compounds

Details Carbamoyloxymethylalkylcarbapenem compounds Carbamoyloxymethylalkylcarbapenem compounds

C - Chemistry, Metallurgy

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C07D 487/04 (2006.01) A61K 31/40 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1283416

Shionogi & Co., Ltd. Carbamoyloxymethylalkylcarbapenem compounds Inventor: Shoichiro Uyeo - Abstract - A highly efficient antibacterial (1,5R,6S)-6-[(1R)-1 hydroxy- ethyl]-2-optionally alkylated carbamoyloxymethyl-1-alkyl-1-carba- pen-2-em-3-carboxylic acid and its derivative represented by formula 1 and its preparation are given: Image (I) (wherein, R1 is hydrogen or a hydroxy-protecting group; R2 is lower alkyl; R3 is hydrogen or lower alkyl; and R4 is hydrogen or a salt- or ester-forming group).

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