Carbamoylpyrrolidone derivatives and drugs for senile dementia

Details Carbamoylpyrrolidone derivatives and drugs for senile dementia Carbamoylpyrrolidone derivatives and drugs for senile dementia

C - Chemistry, Metallurgy

07

D

167/207, 260/259

C07D 207/267 (2006.01) C07D 207/263 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/10 (2006.01)

Patent

CA 1305148

ABSTRACT OF TEE INVENTION A compound of the formula: Image (I) (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group, Image one of A and B is Image and the other is: Image : R1 is hydrogen or C1-C? alkyl; Z1 is phenyl, benzyl, or isoxazolyl each optionally substituted by A halogen, methoxy, or methyl group; Z2 is hydrogen, C1-C? alkyl, C2-C? alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z1 and Z2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group; Z3 is C1-C? hydroxyalkyl, di(C1-C? alkyl)sulfamoyl, 6-membered hetero- cyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group; Z4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z? is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z? is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3) or its pharmaceutical acceptable acid addition salt being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.

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