Carbanucleoside synthesis and novel intermediate compounds...

Details Carbanucleoside synthesis and novel intermediate compounds... Carbanucleoside synthesis and novel intermediate compounds...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) C07D 239/47 (2006.01) C07D 239/54 (2006.01) C07D 319/08 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01) C07D 473/34 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2705953

Anti-virally active carbanucleosides such as entecavir are prepared by a process which utilizes, throughout the synthesis, an aromatic protectant group for the hydroxyl and the alkyl hydoxy groups of the starting material, removed as the final step of a multi-step synthesis. Such protectant groups yield intermediates which are solid and therefore easily purified at various stages of the process, for an economical and relatively fast process for synthesizing the final product.

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