Carbapenem antibacterial compounds, compositions and methods...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) C07D 477/00 (2006.01) C07D 477/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2306632

The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula (I). Pharmaceutical compositions and methods of use are also included.

L'invention concerne des agents antibactériens au carbapénème tricyclique dans lesquels le noyau de carbapénème est condensé avec un noyau carbocyclique à 6 chaînons. De plus, ce composé est substitué par divers groupes dont au moins un groupe cationique. Les composés sont représentés par la formule (I). L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation.

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