Carbapenem antibacterial compounds, compositions containing...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/395 (2006.01) C07D 477/14 (2006.01)

Patent

CA 2303954

The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a -Z-CH2 group. The naphthosultam is further substituted with various substituent groups including cationic groups. The compounds are represented by formula (I). Pharmaceutical compositions and methods of use are also included.

La présente invention porte sur des agents antibactériens de carbapenem dans lesquels le noyau de carbapenem est substitué en position 2 par un naphtosultan lié par un groupe -Z-CH¿2?. Le naphtosultan est également substitué par divers groupes substituants comprenant des groupes cationiques. Les composés de cette invention sont représentés par la formule (I). L'invention porte également sur des compositions pharmaceutiques et sur leurs procédés d'utilisation.

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