Carbapenem antibiotics

Details Carbapenem antibiotics Carbapenem antibiotics

C - Chemistry, Metallurgy

07

D

260/242, 260/272

C07D 487/04 (2006.01) C07D 477/20 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1272719

ABSTRACT Disclosed are novel carbapenem derivatives characterized by a non-hydrogen substituent in the 1- position of the carbapenem ring and a 2-substituent of the formula Image in which A represents cyclopentylene, cyclohexylene or C2- C6 alkylene optionally substituted by one or more C1-C4 alkyl groups; R5 represents either (a) an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic- aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radical or (b) a divalent phenylene or C1-C4 alkylene group joined to the Image ring so as to form a bridged polycyclic group; and Image represents a quaternized nitrogen-containing non-aromatic heterocycle. Such derivatives are useful as potent anti- bacterial agents.

531212

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