Carbapenem compounds and production thereof

Details Carbapenem compounds and production thereof Carbapenem compounds and production thereof

C - Chemistry, Metallurgy

07

D

167/211, 167/233

C07D 487/04 (2006.01) A61K 31/40 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 403/06 (2006.01) C07D 477/20 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1281720

ABSTRACT The present invention is directed to compounds of the formula: Image wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxy- carbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: (1) Image wherein R3 and R4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group, (2) -ZCOR5 wherein Z represents -NH- or -O- and R5 represents an amino - 2 - group, a mono(lower)alkylamino group, a di(lower)alkylamino group, a lower alkyloxy group or a lower alkyl group, (3) Image wherein R6 represents a hydrogen atom or a lower alkyl group, (4) -CH=N-R7 wherein R7 represents a mono(lower)alkylamino group, a di- (lower)alkylamino group or a lower alkyloxy group, or (5) Image wherein R8, R9 and R10, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, Y represents a hydrogen atom, a conventional protecting group for an amino group or a group of either one of the following formulas: (6) Image wherein R11 and R12, which may be the same or different, each represents a hydrogen atom or a lower alkyl group or (7) Image wherein R6 is as defined above and n is an integer of 1 to 6, and pharmacologically acceptable salts thereof. The com- pounds of the present invention are useful as antimicrobial agents.

494815

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