C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 477/14 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)
Patent
CA 2155493
The present invention relates to carbapenems and provides a compound of the formula (I) (see formula I) wherein R1 is hydroxymethyl, 1-hydroxyethyl or 1-fluoroethyl; R2 is hydrogen or C1-4alkyl; X1 is oxygen or sulphur; and A is of the formula (see formula II) which is optionally substituted on either ring and wherein B is of the formula -CH2-C(=O)-(CH2)n-, -C(=O)-(CH2)n1-, -C(=O)-CH=CH-X2-, -C(=O)CH2CH2X2-, -(CH2)n C(=O)NH- or -CH=CHC(=O)NH- wherein n is 1 or 2, n1 is 2 or 3 and X2 is NH, O or S; and a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
Astrazeneca Uk Limited
Smart & Biggar
Zeneca Ltd.
Zeneca-Pharma Sa
LandOfFree
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