Carbapenem derivatives containing a bicyclic ketone...

Details Carbapenem derivatives containing a bicyclic ketone... Carbapenem derivatives containing a bicyclic ketone...

C - Chemistry, Metallurgy

07

D

C07D 477/14 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) C07F 7/10 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2155493

The present invention relates to carbapenems and provides a compound of the formula (I) (see formula I) wherein R1 is hydroxymethyl, 1-hydroxyethyl or 1-fluoroethyl; R2 is hydrogen or C1-4alkyl; X1 is oxygen or sulphur; and A is of the formula (see formula II) which is optionally substituted on either ring and wherein B is of the formula -CH2-C(=O)-(CH2)n-, -C(=O)-(CH2)n1-, -C(=O)-CH=CH-X2-, -C(=O)CH2CH2X2-, -(CH2)n C(=O)NH- or -CH=CHC(=O)NH- wherein n is 1 or 2, n1 is 2 or 3 and X2 is NH, O or S; and a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

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