Carbapenems, their production and use

Details Carbapenems, their production and use Carbapenems, their production and use

C - Chemistry, Metallurgy

07

D

167/208, 260/260

C07D 487/04 (2006.01) A61K 31/395 (2006.01) C07D 205/08 (2006.01) C07D 409/04 (2006.01) C07D 477/20 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1263117

ABSTRACT A compound of the general formula: ( I ) Image wherein X is a lower alkylene group which may optionally be substituted by a hydroxyl group, or a lower alkenylene group, Y is (1) a lower alkyl group, (2) a cycloalkyl group containing 3 to 8 carbon atoms, (3) a lower alxenyl group, (4) an aryl group, (5) an aralkyl group or (6) a 3- to 8- membered heterocyclic group, or the partial structural formula Y-SO2-X-, with X and Y being combined with each other, represents a group of the formula: Image wherein ? is an integer of 0 to 3, and m and n each is an integer of 0 to 6, provided that the sum of m and n is in the range of 2 to 6, and R is a hydrocarbon group which may optionally be substituted or a 3- to 8-membered hetero- cyclic group, or a pharmaceutically acceptable salt thereof a method of production thereof and use thereof. The compound (I) has antimicrobial and .beta.-lactamase inhibitory activities.

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