C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/318, 260/276
C07D 209/88 (2006.01) C07D 317/64 (2006.01) C07D 403/12 (2006.01)
Patent
CA 1129416
ABSTRACT OF THE DISCLOSURE New carbazolyl-(4)-oxypropanolamine derivatives and their process of preparation are provided of formula (I): Image (I) wherein R1 is a hydrogen atom, a lower alkanoyl radical or an aroyl radical: R2 is a hydrogen atom, a lower alkyl radical or an ar-lower-alkyl radical: R3 is a hydrogen atom or a lower alkyl radical, R4 is a hydrogen atom or a lower alkyl radical or, when X is an oxygen atom, together with R5 can also represent a -CH2-O- radical X is a valency bond. a -CH2- radical or an oxygen or sulphur atom: Ar is a mono- or bicyclic hydrocarbon radical or a pyridyl radical and R5 and R6, which can be the same or different, are selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, ar-lower-alkyloxy, lower alkylthio, lower alkylsulphinyl and lower alkylsulphonyl: or R5 and R6 together represent a methylenedioxy radical: and the pharmaceutically acceptable, pharmacologically or physiologically compatible acid addition salts thereof with non-toxic physiologically acceptable inorganic or organic acids, the new derivatives show, in pharmacological tests, vasodilatory and .beta.-receptor-blocking actions they are, there- fore, suitable for the treatment of prophylaxis of circulatory and cardiac diseases, for example, of hypertension and angina pectoris.
324667
Dietmann Karl
Kampe Wolfgang
Roesch Egon
Sponer Gisbert
Thiel Max
Boehringer Mannheim G.m.b.h.
Sherman
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