C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 239/46 (2006.01) C07D 239/52 (2006.01) C07D 239/54 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2165419
The present invention is directed to a class of novel carbo-acyclic derivatives having formulas (I) and (II) and their use as anti-viral and anti-neoplastic agents, Wherein X1 and X2 are each independently hydrogen, fluorine, or chlorine, R is hydrogen or hydroxymethyl, J is a radical of formulas (a), (b) and (c). Y1 is a CH group, a CCI group, a CBr group or a CNH2 group, Y2 and Y3 are each independently nitrogen or a CH group, Y1 is a CH group, a CCI group, a CBr group or a CNH2 group, Y2 and Y3 are each independently nitrogen or a CH group, Y4 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy or halogen, Y5 is NH2 or C1-C4 alkoxy, Q is NH2, NHOH, NHCH3, OH, or hydrogen, and V is hydrogen, halogen or NH2; or a pharmaceutically acceptable salt thereof.
La présente invention concerne une classe de nouveaux dérivés carbo-acycliques ayant les formules (I) et (II), ainsi que leur utilisation comme agents antiviraux et antinéoplasiques. Dans ces formules: X1 et X2 représentent chacun indépendamment hydrogène, fluor ou chlore, R représente hydrogène ou un hydroxyméthyle, J représente un radical des formules (a), (b), (c), dans lesquelles Y1 représente un groupe CH, un groupe CCl, un groupe CBr ou un groupe CNH2, et Y2 et Y3 représentent chacun indépendamment azote ou un groupe CH, Y4 représente hydrogène, alkyleC1-C4, alcoxyC1-C4 ou halogène, Y5 représente NH2 ou alcoxyC1-C4, Q représente NH2, NHOH, NHCH3, OH ou hydrogène et V représente hydrogène, halogène ou NH2. L'invention concerne également un sel de ces composés acceptable sur le plan pharmaceutique.
Miller Shawn C.
Sabol Jeffrey S.
Sunkara Sai Prasad
Merrell Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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