Carbocyanine dyes for tandem, photodiagnostic and...

Details Carbocyanine dyes for tandem, photodiagnostic and... Carbocyanine dyes for tandem, photodiagnostic and...

A - Human Necessities

61

B

A61B 10/00 (2006.01) A61B 5/00 (2006.01) A61B 8/00 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2463994

Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.

L'invention concerne de nouveaux agents photothérapeutiques et photodiagnostiques spécifiques des tumeurs. Ces composés sont constitués d'un colorant carbocyanine permettant la visualisation, d'un photosensibilisant permettant un traitement photodynamique, et d'un peptide présentant une avidité pour les récepteurs tumoraux, permettant une distribution dirigée de la sonde et de l'agent phototoxique dans les tissus malades. La combinaison de ces éléments permet d'exploiter pleinement les propriétés spécifiques et efficaces de chaque composant et d'assurer une gestion efficace des soins aux patients.

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