C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/22 (2006.01) C07D 311/80 (2006.01) C07D 311/92 (2006.01) C07D 311/94 (2006.01) C07D 313/08 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2637897
This invention discloses novel gamma secretase inhibitors of the formula: R2and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
L'invention concerne de nouveaux inhibiteurs de la gamma secrétase représentés par la formule: R2 et R3, ou R2 et R4, ou R3 et R4 , qui, conjointement avec les atomes auxquels ils sont liés, peuvent former un anneau cycloalkyle ou un anneau hétérocycloalkyle condensé. L'anneau cycloalkyle ou l'anneau hétérocycloalkyle peut être éventuellement substitué par au moins un substituant. Par ailleurs, un ou plusieurs composés de formule (I), ou des formulations renfermant ces composés, peuvent servir, par exemple, dans le traitement de la maladie d'Alzheimer.
Asberom Theodros
Bara Thomas
Bennett Chad E.
Burnett Duane A.
Caplen Mary Ann
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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