Carbocyclic and heterocyclic fused-ring quinolinecarboxylic...

Details Carbocyclic and heterocyclic fused-ring quinolinecarboxylic... Carbocyclic and heterocyclic fused-ring quinolinecarboxylic...

C - Chemistry, Metallurgy

07

D

C07D 221/18 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 491/147 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2170349

This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, selected from compounds of formulas (1, 2, 3, or 4), or pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.

Cette invention concerne des composés d'acide quinoléine-carboxylique à anneaux carbocycliques et hétérocycliques condensés, sélectionnés parmi les compsés des formules (1, 2, 3 ou 4), ou parmi des sels de ceux-ci de qualité pharmaceutique. Cette invention qui concerne également des compositions pharmaceutiques faisant intervenir de tels composés, porte aussi sur les procédés d'utilisation de tels composés pour le traitement et/ou la prévention des rejets de greffes d'organes, des réactions du greffon contre l'hôte, des affections auto-immunes, des affections inflammatoires chroniques, et également, mais sans que l'énumération soit exhaustive, du psoriasis et de l'arthrite rhumatoïde ainsi que du cancer, chez les mammifères.

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