Carbocyclic compounds

Details Carbocyclic compounds Carbocyclic compounds

C - Chemistry, Metallurgy

07

C

167/179, 260/325

C07C 311/51 (2006.01) A61K 31/18 (2006.01) C07D 295/182 (2006.01)

Patent

CA 1332604

ABSTRACT This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R11 and R12 are defined in the specification) derived from acylsulfon- amide derivatives of .alpha.-carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharma- ceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture. Image I

596513

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