Carbocyclic hydrazino inhibitors of copper-containing amine...

A - Human Necessities – 61 – K

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A61K 31/15 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07C 243/20 (2006.01) C07D 273/00 (2006.01)

Patent

CA 2451569

The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R1 to R11 are as defined herein.

La présente invention concerne des composés hydrazino carbocycliques fonctionnant comme des inhibiteurs des amines oxydases à teneur en cuivre communément appelées amine oxydases sensibles au semicarbazide (SSAO), y compris la SSAO humaine appelée protéine-1 d'adhésion vasculaire (VAP-1). Ces inhibiteurs de SSAO sont utiles à des fins thérapeutiques en tant que médicaments pour traiter des affections et des maladies parmi lesquelles, entre autres, plusieurs affections et maladies inflammatoires (en particulier, des affections inflammatoires chroniques, telles que l'arthrite chronique, les maladies intestinales inflammatoires, et les dermatoses chroniques de la peau), les maladies associées au métabolisme des glucides et aux aberrations de la différentiation ou de la fonction des adipocytes et de la fonction cellulaire des muscles lisses, et les maladies vasculaires. Les nouveaux composés sont représentés par la formule générale: ou un sel, un hydrate, ou un solvate pharmaceutiquement acceptable, dans laquelle R?1¿ à R?11¿ sont tels que définis dans le descriptif.

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