Carbocyclic nucleoside analogs

Details Carbocyclic nucleoside analogs Carbocyclic nucleoside analogs

A - Human Necessities

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A61K 31/505 (2006.01) C07C 215/42 (2006.01) C07C 271/18 (2006.01) C07C 271/20 (2006.01) C07C 271/24 (2006.01) C07C 275/50 (2006.01) C07D 213/69 (2006.01) C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 251/16 (2006.01) C07D 253/065 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07F 7/18 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2001318

-232- CARBOCYCLIC NUCLEOSIDE ANALOGS ABSTRACT OF THE DISCLOSURE A compound of the formula: Image wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, OH, -CH2OH, -CH2OR20 wherein R20 i8 C1 to C6 alkyl, -CH20C(O)R21 wherein R21 is C1 to C10 alkyl, -CH20C(O)CH(R22)(NHR23) wherein R22 is tha side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2C1, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -233- -CO)2R1, -CH2OH2OH, -CH2CH2OR20 R20 is as defined above, -CH2CH20C(O)R21 wherein R21 is as defined above, -CH2CH20C(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above, -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to 10 alkyl and R3 is hydrogen, C1 to C10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof. (11-1088P)

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