Carbocyclic nucleoside analogs as rna-antivirals

Details Carbocyclic nucleoside analogs as rna-antivirals Carbocyclic nucleoside analogs as rna-antivirals

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61P 31/14 (2006.01) C07D 473/02 (2006.01) C07D 473/04 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C07D 473/20 (2006.01) C07D 473/22 (2006.01) C07D 473/24 (2006.01) C07D 473/26 (2006.01) C07D 473/28 (2006.01) C07D 473/30 (2006.01) C07D 473/32 (2006.01) C07D 473/34 (2006.01) C07D 473/36 (2006.01) C07D 473/38 (2006.01) C07D 473/40 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2488842

The present invention provides carbocyclic nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such carbocyclic nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the carbocyclic nucleoside compounds of the present invention

La pr~sente invention concerne des compos~s de nucl~osides carbocycliques et certains de leurs d~riv~s qui sont des inhibiteurs de l'ARN polym~rase ARN-d~pendante virale. Ces compos~s sont des inhibiteurs de la r~plication virale de l'ARN ARN-d~pendante et sont utiles pour le traitement d'une infection virale ARN ARN-d~pendante. Ces compos~s sont tout particuli­rement utiles comme inhibiteurs de la polym~rase NS5B du virus de l'h~patite C (VHC), comme inhibiteurs de la r~plication du VHC, et/ou pour le traitement d'une infection par le virus de l'h~patite C. L'invention concerne ~galement des compositions pharmaceutiques contenant ces compos~s de nucl~osides carbocycliques seuls ou combin~s ~ d'autres agents actifs contre une infection virale ARN ARN-d~pendante, en particulier une infection par le virus de l'h~patite C. L'invention concerne ~galement des m~thodes permettant d'inhiber l'ARN polym~rase ARN-d~pendante, d'inhiber la r~plication virale de l'ARN ARN-d~pendante, et/ou de traiter une infection virale ARN ARN-d~pendante, utilisant les compos~s de nucl~osides carbocycliques de la pr~sente invention.

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