Carbocyclic side chain containing metalloprotease inhibitors

Details Carbocyclic side chain containing metalloprotease inhibitors Carbocyclic side chain containing metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 317/72 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01) C07C 311/19 (2006.01) C07C 311/25 (2006.01) C07C 311/29 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 233/72 (2006.01) C07D 235/02 (2006.01) C07D 263/20 (2006.01) C07D 265/10 (2006.01) C07D 265/32 (2006.01) C07D 275/02 (2006.01) C07D 295/096 (2006.01) C07D 319/08 (2006.01)

Patent

CA 2403778

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I) where R1, R2, n, A, E, E', L, L', G and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

L'invention concerne des composés inhibiteurs de métalloprotéases et efficaces dans le traitement de pathologies caractérisées par une suracitivité de ces enzymes. Plus particulièrement, ces composés comportent une structure représentée par la formule (I), dans laquelle R?1¿, R?2¿, n, A, E, E', L, L', G et Z sont tels que présentés dans le descriptif et les revendications de l'invention. Cette invention concerne également des isomères, diastereomères et énantiomères optiques de formule (I), ainsi que leurs sels, amides biohydrolysables, esters et imides acceptables sur le plan pharmaceutique. L'invention porte également sur des compositions pharmaceutiques qui renferment ces composés et sur des méthodes de traitement de maladies en rapport avec des métalloprotéases au moyen des composés ou compositions pharmaceutiques susmentionnés.

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