C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/00 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) C07C 311/07 (2006.01) C07C 311/10 (2006.01) C07C 311/11 (2006.01) C07C 311/13 (2006.01) C07C 311/14 (2006.01) C07C 311/19 (2006.01) C07C 311/20 (2006.01) C07C 311/27 (2006.01) C07C 311/29 (2006.01) C07C 323/67 (2006.01) C07D 207/16 (2006.01) C07D 493/08 (2006.01) C08B 37/16 (2006.01) A61K 31/73 (1990.01)
Patent
CA 2113787
ABSTRACT (1 ) Prostaglandin (PG) E2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): Image (I) cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient, (2) carbocyclic sulfonamides represented by the compound of the formula (II): Image (II) cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore, (4) PGE2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient. The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE2 antagonists, and an uterine contractile activity, a promaoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE2 agonists, because they bind onto PGE2 receptor and have an activity of antagonist or agonist against the action thereof. 112
Hamanaka Nobuyuki
Miyamoto Tsumoru
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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