Carbohydrate-based ligand library, assay and method

Details Carbohydrate-based ligand library, assay and method Carbohydrate-based ligand library, assay and method

C - Chemistry, Metallurgy

07

H

C07H 15/02 (2006.01) A61K 39/385 (2006.01) C07H 1/00 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2249290

A carbohydrate-based library is described which comprises a plurality of distinct sugar-containing ligands each bound to a resolvable portion of a solid support. The library is constructed by a method that includes a glycosyl bond-forming step. Libraries of differing sizes can be prepared by the method of the present invention in which large numbers of distinct species are made substantially concurrently by the formation of glycosyl bonds among many types of participants. Moreover, an assay, which allows the substantial simultaneous screening of essentially all the members of the library, is described. The isolation of novel ligands of low-affinity is thus facilitated.

L'invention se rapporte à une bibliothèque de ligands à base d'hydrates de carbone, qui comprend une pluralité de ligands distincts contenant du sucre, chacun lié à une partie résoluble d'un support solide. La bibliothèque est construite selon un procédé qui comprend une étape de formation d'une liaison glycosyle. Des bibliothèque de tailles différentes peuvent être constituées selon le procédé décrit dans cette invention, dans lesquelles un grand nombre d'espèces distinctes sont réalisées sensiblement concurremment par formation de liaisons glycosyles entre de nombreux types de participants. En outre, l'invention porte sur un dosage, qui permet le criblage sensiblement simultané de pratiquement tous les membres de la bibliothèque. L'isolement de ligands nouveaux de faible affinité est ainsi facilité.

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