Carbohydrate-based synthetic vaccines for hiv

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/10 (2006.01) A61K 31/702 (2006.01) A61K 39/21 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07H 3/06 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2504755

The present invention relates to a constructed oligosaccharide cluster, optionally bonded to an immunogenic protein, that can be administered to a subject to induce an immune response for increasing production of 2G12 and/or used in assays as reactive sites for determining compounds that inactivate and/or bind the high-mannose oligosaccharide cluster. Compositions comprising these clusters, methods of using these clusters and compositions are disclosed.

La présente invention se rapporte à un agrégat d'oligosaccharides élaborés, éventuellement lié à une protéine immunogène, qui peut être administré à un sujet afin d'induire chez ce sujet une réponse immunitaire permettant d'accroître la production de 2G12 et/ou qui peut être utilisé dans des analyses en tant que site réactif pour la détermination de composés qui inactivent et/ou se lient à l'agrégat d'oligosaccharides à haute teneur en mannose. L'invention se rapporte également à des compositions comportant ces agrégats ainsi qu'à des procédés d'utilisation de ces agrégats et compositions.

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