C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/199, 260/233
C07H 13/12 (2006.01) A61K 31/70 (2006.01) C07H 11/00 (2006.01) C07H 15/04 (2006.01)
Patent
CA 2040905
Carbohydrate derivatives comprising a trisaccharide unit having the general formula I (see formula I) in which R is alkyl, aryl, or aralkyl: Q is alkyl, aryl, aralkyl, or SO3-: A and B are independently selected from hydrogen, alkyl, aryl, aralkyl, or a carbohydrate group; and the charged moieties are compensated by counter- ions. The carbohydrate derivatives of this invention possess anti-thrombotic activity, and especially they have potent anti-X a activity without activating thrombin via anti-thrombin-III (AT-III) and smooth muscle cell proli- feration inhibiting activity.
Petitou Maurice
Van Boeckel Constant A. A.
Akzo N.v.
Fetherstonhaugh & Co.
Sanofi S.a.
Sanofi-Aventis
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