Carbohydrate derivatives comprising a trisaccharide unit

C - Chemistry – Metallurgy – 07 – H

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167/199, 260/233

C07H 13/12 (2006.01) A61K 31/70 (2006.01) C07H 11/00 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2040905

Carbohydrate derivatives comprising a trisaccharide unit having the general formula I (see formula I) in which R is alkyl, aryl, or aralkyl: Q is alkyl, aryl, aralkyl, or SO3-: A and B are independently selected from hydrogen, alkyl, aryl, aralkyl, or a carbohydrate group; and the charged moieties are compensated by counter- ions. The carbohydrate derivatives of this invention possess anti-thrombotic activity, and especially they have potent anti-X a activity without activating thrombin via anti-thrombin-III (AT-III) and smooth muscle cell proli- feration inhibiting activity.

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