Carbohydrate-derivatized liposomes for targeting cellular...

Details Carbohydrate-derivatized liposomes for targeting cellular... Carbohydrate-derivatized liposomes for targeting cellular...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2560241

Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor- specific anchor, on its outer surface. Targeting systems are also disclosed. Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.

L'invention concerne des méthodes préférées d'administration intracellulaire d'un agent actif à une cellule réservoir infectée ou susceptible d'être infectée par un agent infectieux, tel que le VIH. L'agent actif fait partie d'un complexe lipide-agent actif dont la surface extérieure présente un ligand de ciblage, tel qu'un élément d'ancrage spécifique du récepteur CTL/CTLD. L'invention concerne également des systèmes de ciblage constitués de complexes lipide-agent actif dont la surface extérieure présente des ligands de ciblage, tels que des dérivés de fucose et de polyfucose. Ces agents actifs comprennent des lectines d'origine végétale, telles que Con-A et MHL, et d'autres médicaments. Les méthodes et systèmes de ciblage de l'invention peuvent être utilisés dans le traitement du VIH ou d'autres maladies infectieuses ou non infectieuses.

Affiliated with

Also associated with

Rating

Carbohydrate-derivatized liposomes for targeting cellular... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbohydrate-derivatized liposomes for targeting cellular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbohydrate-derivatized liposomes for targeting cellular... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1931829