Carbohydrate-mediated coupling of peptides to immunoglobulins

Details Carbohydrate-mediated coupling of peptides to immunoglobulins Carbohydrate-mediated coupling of peptides to immunoglobulins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/47 (2006.01) A61K 39/145 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/11 (2006.01) C07K 14/33 (2006.01) C07K 14/545 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/32 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2227326

The present invention relates to methods for enzymatically coupling peptides to immunoglobulin molecules via carbohydrate residues of immunoglobulin molecules, and to immunoglobulin-carbohydrate-linked peptide ("ICLP") conjugates produced by such methods. ICLP conjugates have been found to be superior in eliciting an immune response when compared to unconjugated peptide.

Procédés de couplage enzymatique de peptides à des molécules d'immunoglobuline par l'intermédiaire de résidus glucide de molécules d'immunoglobuline. L'invention concerne également des conjugués peptide-immunoglobuline liés par glucide ("ICLP"), obtenus par ces procédés. Les conjugués ICLP apparaissent plus aptes à susciter une réponse immunitaire que les peptides non conjugués.

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