C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/44 (2006.01) A61K 31/7028 (2006.01) A61K 39/395 (2006.01) A61K 47/22 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01) C07H 15/12 (2006.01) C07H 15/26 (2006.01) C07K 14/195 (2006.01) C07K 14/33 (2006.01) C07K 16/12 (2006.01) C07K 17/10 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2511084
The present invention relates to carbohydrate-phosphorylcholine conjugate molecule, and more particularly to phosphorylcholine-N-acetyl-D- galactosamine molecules and their use for treating and/or preventing a bacterial infection of the respiratory tract. More specifically, in this present application, the inventors aimed at raising high-affinity antibodies against Chop preferably in its bacterial context in order to target several pathogens of the respiratory tract. By mimicking the S. pneumoniae model, the inventors preferably synthesized two carbohydrate-Chop (GalNAc-Chop) protein conjugates and showed that these immunogens induce hapten-specific antibodies which recognize two major bacterial pathogens of the respiratory tract : such as a Gram-positive bacterium, S. pneumoniae, and a Gram-negative bacterium, N. meningitidis.
Alonso Jean-Michel
Bay Sylvie
England Patrick
Huteau Valerie
Lafaye Pierre
Institut Pasteur
Robic
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