C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 9/00 (2006.01) A61P 15/10 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2437718
Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
L'invention concerne des composés représentés par la formule (I), des sels et des solvates de ceux-ci, et l'utilisation de ces composés comme agents thérapeutiques.
Bombrun Agnes
Brown Raymond F.
Daugan Alain Claude-Marie
Orme Mark W.
Sawyer Jason Scott
Lilly Icos Llc
Ridout & Maybee Llp
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