Carboline derivatives useful in the inhibition of angiogenesis

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2559408

In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

La présente invention a trait à des composés d'inhibition de l'expression de VEGF qui ont été soumis à une identification post-transcriptionnelle, et à leurs procédés d'utilisation. Dans un mode de réalisation, l'invention a trait à des composés utiles dans l'inhibition de la production de VEGF, dans l'inhibition de l'angiogenèse, et/ou dans le traitement du cancer, de la rétinopathie diabétique ou la dégénérescence maculaire exsudative. Dans un autre mode de réalisation, l'invention a trait à des procédés pour l'inhibition de la production de VEGF, dans l'inhibition de l'angiogenèse, et/ou dans le traitement du cancer, de la rétinopathie diabétique ou la dégénérescence maculaire exsudative mettant en oeuvre les composés de l'invention.

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